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DE-1.44

Submodule 12 genes

Lysosomal and mitochondrial metabolic enzymes

This module contains 12 genes including GLA, IMMT, CSTF2, GUSB, and AK2, with enrichment for lysosomal enzymes and mitochondrial proteins involved in metabolic processes. Knockdown of SOX17 activates this module, while knockdown of EOMESODERMIN represses it. This pattern suggests the module is suppressed during normal endoderm differentiation but can be induced when SOX17 function is removed.

Key terms: glycoside catabolic process glycoside metabolic process glycosyl compound catabolic process carbohydrate derivative catabolic process Notable genes: GLA IMMT CSTF2 GUSB AK2 FUCA2 ANAPC5 SF3A2

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (12)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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