Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZYG11B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZYG11B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZYG11B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:52,552,164–52,554,055 | 173.1 kb | Distal (>10kb) Multiome | 955 | |
| chr1:52,602,249–52,602,924 | 123.9 kb | Distal (>10kb) Multiome | 267 | |
| chr1:52,632,811–52,633,791 | 93.2 kb | Distal (>10kb) Multiome | 269 | |
| chr1:52,662,669–52,663,405 | 63.4 kb | Distal (>10kb) Multiome | 285 | |
| chr1:52,697,629–52,698,936 | 28.1 kb | Distal (>10kb) Multiome | 997 | |
| chr1:52,702,879–52,703,689 | 23.3 kb | Distal (>10kb) Multiome | 872 | |
| chr1:52,726,263–52,726,954 | 57 bp | At TSS Multiome | 681 | |
| chr1:52,842,499–52,843,778 | 116.3 kb | Distal (>10kb) Multiome | 687 | |
| chr1:52,921,024–52,921,900 | 195.2 kb | Distal (>10kb) Multiome | 693 | |
| chr1:52,926,942–52,927,992 | 200.9 kb | Distal (>10kb) Multiome | 610 | |
| chr1:53,196,600–53,197,254 | 470.3 kb | Distal (>10kb) Multiome HiCAR | 711 |
Genomic view of the ZYG11B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.