Involved in mitotic spindle assembly checkpoint signaling and protein localization to kinetochore. Located in kinetochore. Part of RZZ complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZWILCH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZWILCH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZWILCH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:66,252,061–66,253,967 | 252.8 kb | Distal (>10kb) Multiome | 412 | |
| chr15:66,293,215–66,294,349 | 211.6 kb | Distal (>10kb) Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 148.5 kb | Distal (>10kb) Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 118.5 kb | Distal (>10kb) Multiome | 899 | |
| chr15:66,472,216–66,473,164 | 32.7 kb | Distal (>10kb) Multiome | 208 | |
| chr15:66,497,104–66,498,247 | 7.5 kb | Proximal (<10kb) Multiome | 1044 | |
| chr15:66,504,543–66,505,655 | 206 bp | At TSS Multiome | 940 | |
| chr15:66,567,056–66,567,492 | 62.0 kb | Distal (>10kb) Multiome | 294 | |
| chr15:66,592,463–66,593,143 | 87.5 kb | Distal (>10kb) Multiome | 154 | |
| chr15:66,621,672–66,622,446 | 116.9 kb | Distal (>10kb) Multiome | 271 | |
| chr15:66,630,856–66,631,340 | 125.8 kb | Distal (>10kb) Multiome | 284 | |
| chr15:66,670,796–66,671,740 | 165.9 kb | Distal (>10kb) Multiome | 241 | |
| chr15:66,673,331–66,673,903 | 168.4 kb | Distal (>10kb) Multiome | 192 | |
| chr15:66,679,362–66,680,264 | 174.6 kb | Distal (>10kb) Multiome | 541 | |
| chr15:66,691,568–66,692,527 | 186.8 kb | Distal (>10kb) Multiome | 33 | |
| chr15:66,698,421–66,699,404 | 193.9 kb | Distal (>10kb) Multiome | 321 | |
| chr15:66,700,619–66,702,650 | 195.8 kb | Distal (>10kb) Multiome | 844 | |
| chr15:66,773,918–66,774,633 | 269.2 kb | Distal (>10kb) Multiome | 524 |
Genomic view of the ZWILCH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.