Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF853. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF853 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF853, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,348,284–6,349,527 | 266.6 kb | Distal (>10kb) Multiome | 787 | |
| chr7:6,374,107–6,375,074 | 241.2 kb | Distal (>10kb) Multiome | 778 | |
| chr7:6,447,046–6,448,661 | 167.6 kb | Distal (>10kb) Multiome | 944 | |
| chr7:6,483,337–6,484,560 | 131.4 kb | Distal (>10kb) Multiome | 748 | |
| chr7:6,502,814–6,505,187 | 111.5 kb | Distal (>10kb) Multiome | 573 | |
| chr7:6,516,399–6,516,954 | 99.0 kb | Distal (>10kb) Multiome | 245 | |
| chr7:6,526,260–6,527,132 | 88.9 kb | Distal (>10kb) Multiome | 313 | |
| chr7:6,530,620–6,531,774 | 84.4 kb | Distal (>10kb) Multiome | 296 | |
| chr7:6,536,237–6,537,265 | 78.7 kb | Distal (>10kb) Multiome | 223 | |
| chr7:6,577,282–6,577,787 | 38.1 kb | Distal (>10kb) Multiome | 840 | |
| chr7:6,589,551–6,590,781 | 25.6 kb | Distal (>10kb) Multiome | 802 | |
| chr7:6,614,875–6,616,376 | 155 bp | At TSS Multiome | 610 | |
| chr7:6,640,237–6,641,084 | 25.0 kb | Distal (>10kb) Multiome | 238 | |
| chr7:6,663,809–6,664,686 | 48.5 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,706,296–6,707,347 | 91.3 kb | Distal (>10kb) Multiome | 718 | |
| chr7:6,729,225–6,730,453 | 114.1 kb | Distal (>10kb) Multiome | 755 | |
| chr7:6,901,511–6,903,145 | 286.8 kb | Distal (>10kb) Multiome | 232 |
Genomic view of the ZNF853 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.