ZNF852

zinc finger protein 852

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-5 Developmental clusters: GC5

Biological processes 6 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF852 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF852. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF852 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF852

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF852, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:44,337,649–44,339,009	172.0 kb	Distal (>10kb) Multiome HiCAR	1024
chr3:44,477,346–44,478,014	33.0 kb	Distal (>10kb) Multiome	561
chr3:44,510,368–44,511,080	100 bp	At TSS Multiome	607
chr3:44,554,965–44,555,488	44.6 kb	Distal (>10kb) Multiome	434
chr3:44,584,465–44,585,362	74.2 kb	Distal (>10kb) Multiome	388
chr3:44,624,770–44,625,563	114.5 kb	Distal (>10kb) Multiome	686
chr3:44,648,515–44,649,232	138.1 kb	Distal (>10kb) Multiome	554
chr3:44,729,240–44,729,901	219.0 kb	Distal (>10kb) Multiome	780
chr3:44,761,326–44,762,300	251.2 kb	Distal (>10kb) Multiome	966

Genome Browser

Genomic view of the ZNF852 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.