Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF846. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF846 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF846, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,140,232–9,140,885 | 652.7 kb | Distal (>10kb) Multiome HiCAR | 722 | |
| chr19:9,309,252–9,310,462 | 483.3 kb | Distal (>10kb) Multiome HiCAR | 627 | |
| chr19:9,538,339–9,539,009 | 254.5 kb | Distal (>10kb) Multiome | 759 | |
| chr19:9,582,064–9,582,785 | 210.7 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr19:9,584,055–9,584,863 | 208.6 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr19:9,620,792–9,622,027 | 171.8 kb | Distal (>10kb) Multiome HiCAR | 856 | |
| chr19:9,674,791–9,675,456 | 118.0 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 24.5 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 7.3 kb | Proximal (<10kb) Multiome | 727 | |
| chr19:9,790,233–9,790,389 | 4.1 kb | Proximal (<10kb) | 131 | |
| chr19:9,791,515–9,793,483 | 411 bp | At TSS Multiome | 507 | |
| chr19:9,796,236–9,796,485 | 3.1 kb | Proximal (<10kb) | 284 | |
| chr19:9,818,302–9,820,113 | 26.2 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 34.6 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 41.9 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 120.6 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 121.7 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,933,993–9,934,841 | 141.2 kb | Distal (>10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 143.3 kb | Distal (>10kb) Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 234.7 kb | Distal (>10kb) Multiome | 753 | |
| chr19:10,086,000–10,086,942 | 293.1 kb | Distal (>10kb) Multiome | 614 |
Genomic view of the ZNF846 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.