This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and sixteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for ZNF732. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF732 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF732, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:124,212–125,389 | 181.0 kb | Distal (>10kb) Multiome | 490 | |
| chr4:212,417–212,910 | 92.8 kb | Distal (>10kb) Multiome | 155 | |
| chr4:304,967–305,746 | 27 bp | At TSS Multiome | 151 | |
| chr4:336,352–338,341 | 32.2 kb | Distal (>10kb) Multiome | 493 | |
| chr4:473,613–474,432 | 168.7 kb | Distal (>10kb) Multiome | 745 | |
| chr4:498,731–499,543 | 193.7 kb | Distal (>10kb) Multiome | 869 | |
| chr4:575,294–576,132 | 270.0 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the ZNF732 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.