ZNF709

zinc finger protein 709 | FLJ38281

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-2

Biological processes 6 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)nucleus (GO:0005634)nucleus (GO:0005634)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF709 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF709. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF709 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF709

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF709, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:11,639,337–11,640,481	845.0 kb	Distal (>10kb) Multiome HiCAR	660
chr19:11,694,497–11,695,341	789.8 kb	Distal (>10kb) Multiome HiCAR	608
chr19:12,365,585–12,366,054	119.1 kb	Distal (>10kb) Multiome	577
chr19:12,400,090–12,401,657	83.6 kb	Distal (>10kb) Multiome	671
chr19:12,440,217–12,441,483	43.7 kb	Distal (>10kb) Multiome	565
chr19:12,484,131–12,485,387	10 bp	At TSS Multiome	664
chr19:12,495,009–12,495,882	10.6 kb	Distal (>10kb) Multiome	824
chr19:12,550,951–12,551,971	66.7 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	86.9 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	126.1 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	155.4 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	162.9 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	172.4 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	182.0 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	184.7 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	196.6 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	211.8 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	218.4 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	237.6 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	239.3 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	249.9 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	252.3 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	273.0 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	281.5 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	290.6 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	293.1 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	297.9 kb	Distal (>10kb) Multiome	699

Genome Browser

Genomic view of the ZNF709 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.