Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF627. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF627 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF627, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,262,060–11,262,653 | 296.9 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 219.7 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 212.9 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 204.0 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 197.7 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 184.4 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 178.0 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 175.0 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 140.8 kb | Distal (>10kb) Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 137.2 kb | Distal (>10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 124.0 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 79.7 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 76.7 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 54.0 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 30.3 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 23.2 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 20.6 kb | Distal (>10kb) Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 19.3 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,552,003–11,552,215 | 7.2 kb | Proximal (<10kb) | 137 | |
| chr19:11,558,908–11,559,777 | 77 bp | At TSS Multiome | 686 | |
| chr19:11,560,646–11,560,814 | 1.3 kb | Proximal (<10kb) | 310 | |
| chr19:11,587,697–11,587,905 | 9.6 kb | Proximal (<10kb) | 294 | |
| chr19:11,597,206–11,598,107 | 38.1 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 80.4 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 135.6 kb | Distal (>10kb) Multiome | 608 | |
| chr19:11,737,998–11,739,422 | 179.6 kb | Distal (>10kb) Multiome | 704 | |
| chr19:12,139,827–12,140,825 | 580.9 kb | Distal (>10kb) Multiome HiCAR | 594 | |
| chr19:12,639,899–12,640,614 | 1080.9 kb | Distal (>10kb) Multiome HiCAR | 454 | |
| chr19:12,656,871–12,657,566 | 1097.8 kb | Distal (>10kb) Multiome HiCAR | 254 | |
| chr19:12,702,968–12,703,602 | 1143.9 kb | Distal (>10kb) Multiome HiCAR | 121 | |
| chr19:12,789,543–12,790,654 | 1230.7 kb | Distal (>10kb) Multiome HiCAR | 717 | |
| chr19:12,790,960–12,793,231 | 1232.1 kb | Distal (>10kb) Multiome HiCAR | 1015 | |
| chr19:12,793,340–12,794,240 | 1234.3 kb | Distal (>10kb) Multiome HiCAR | 808 |
Genomic view of the ZNF627 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.