Enables identical protein binding activity and transcription coregulator binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in pericentric heterochromatin. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ZNF618. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF618 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF618, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:113,591,435–113,592,161 | 284.5 kb | Distal (>10kb) Multiome | 345 | |
| chr9:113,593,578–113,594,410 | 282.3 kb | Distal (>10kb) Multiome | 433 | |
| chr9:113,634,469–113,635,132 | 241.5 kb | Distal (>10kb) Multiome | 142 | |
| chr9:113,658,015–113,658,473 | 218.1 kb | Distal (>10kb) Multiome | 307 | |
| chr9:113,692,033–113,692,884 | 183.8 kb | Distal (>10kb) Multiome | 99 | |
| chr9:113,876,036–113,876,485 | 85 bp | At TSS Multiome | 213 | |
| chr9:113,885,008–113,885,199 | 8.7 kb | Proximal (<10kb) | 162 | |
| chr9:114,097,958–114,099,449 | 222.3 kb | Distal (>10kb) Multiome | 455 | |
| chr9:114,107,965–114,108,461 | 231.8 kb | Distal (>10kb) Multiome | 481 | |
| chr9:114,153,818–114,154,827 | 277.7 kb | Distal (>10kb) Multiome | 561 | |
| chr9:114,154,931–114,156,548 | 279.2 kb | Distal (>10kb) Multiome | 513 |
Genomic view of the ZNF618 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.