Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF611. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF611 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF611, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:52,492,205–52,493,529 | 242.2 kb | Distal (>10kb) Multiome | 178 | |
| chr19:52,526,868–52,528,322 | 207.6 kb | Distal (>10kb) Multiome | 602 | |
| chr19:52,535,433–52,536,654 | 199.0 kb | Distal (>10kb) Multiome | 273 | |
| chr19:52,558,780–52,559,576 | 175.9 kb | Distal (>10kb) Multiome | 17 | |
| chr19:52,569,672–52,570,898 | 164.8 kb | Distal (>10kb) Multiome | 555 | |
| chr19:52,600,732–52,601,970 | 133.8 kb | Distal (>10kb) Multiome | 412 | |
| chr19:52,637,710–52,638,958 | 96.6 kb | Distal (>10kb) Multiome | 473 | |
| chr19:52,690,252–52,691,142 | 44.4 kb | Distal (>10kb) Multiome | 540 | |
| chr19:52,734,568–52,736,125 | 1.1 kb | Proximal (<10kb) Multiome | 473 | |
| chr19:52,741,322–52,742,486 | 7.2 kb | Proximal (<10kb) Multiome | 114 | |
| chr19:52,786,717–52,787,643 | 51.9 kb | Distal (>10kb) Multiome | 439 | |
| chr19:52,857,376–52,858,206 | 122.7 kb | Distal (>10kb) Multiome | 332 | |
| chr19:52,896,852–52,898,438 | 162.7 kb | Distal (>10kb) Multiome | 488 | |
| chr19:52,922,765–52,923,968 | 188.4 kb | Distal (>10kb) Multiome | 526 | |
| chr19:52,941,909–52,943,216 | 207.7 kb | Distal (>10kb) Multiome | 494 | |
| chr19:52,944,441–52,945,501 | 210.2 kb | Distal (>10kb) Multiome | 238 | |
| chr19:52,945,942–52,946,905 | 211.6 kb | Distal (>10kb) Multiome | 164 | |
| chr19:52,962,371–52,963,594 | 228.0 kb | Distal (>10kb) Multiome | 663 | |
| chr19:52,993,475–52,994,192 | 258.8 kb | Distal (>10kb) Multiome | 160 | |
| chr19:53,027,952–53,028,653 | 293.5 kb | Distal (>10kb) Multiome | 64 |
Genomic view of the ZNF611 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.