Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for ZNF516. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF516 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF516, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:76,301,878–76,302,733 | 192.9 kb | Distal (>10kb) Multiome | 81 | |
| chr18:76,380,736–76,381,271 | 114.2 kb | Distal (>10kb) Multiome | 136 | |
| chr18:76,487,739–76,488,191 | 7.0 kb | Proximal (<10kb) | 53 | |
| chr18:76,490,622–76,496,762 | 1.1 kb | Proximal (<10kb) Multiome | 1037 | |
| chr18:76,503,566–76,504,017 | 8.3 kb | Proximal (<10kb) | 52 | |
| chr18:76,619,324–76,620,729 | 125.0 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the ZNF516 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.