Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF500. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF500 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF500, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:4,474,111–4,474,929 | 292.6 kb | Distal (>10kb) Multiome | 626 | |
| chr16:4,476,027–4,477,237 | 290.8 kb | Distal (>10kb) Multiome | 841 | |
| chr16:4,537,639–4,538,998 | 228.6 kb | Distal (>10kb) Multiome | 1087 | |
| chr16:4,585,331–4,585,992 | 181.6 kb | Distal (>10kb) Multiome | 223 | |
| chr16:4,613,912–4,617,164 | 152.3 kb | Distal (>10kb) Multiome | 1079 | |
| chr16:4,624,301–4,625,703 | 142.5 kb | Distal (>10kb) Multiome | 866 | |
| chr16:4,693,016–4,694,663 | 73.6 kb | Distal (>10kb) Multiome | 730 | |
| chr16:4,733,836–4,735,221 | 32.8 kb | Distal (>10kb) Multiome | 858 | |
| chr16:4,766,728–4,767,628 | 32 bp | At TSS Multiome | 795 | |
| chr16:4,768,438–4,769,162 | 1.6 kb | Proximal (<10kb) Multiome | 677 | |
| chr16:4,769,436–4,769,725 | 2.2 kb | Proximal (<10kb) | 106 | |
| chr16:4,801,836–4,803,175 | 35.1 kb | Distal (>10kb) Multiome | 743 | |
| chr16:4,846,559–4,848,209 | 80.2 kb | Distal (>10kb) Multiome | 803 | |
| chr16:4,936,143–4,937,673 | 170.1 kb | Distal (>10kb) Multiome | 655 | |
| chr16:4,943,173–4,943,813 | 176.2 kb | Distal (>10kb) Multiome | 609 | |
| chr16:4,957,489–4,958,782 | 190.9 kb | Distal (>10kb) Multiome | 802 | |
| chr16:5,010,592–5,011,132 | 243.6 kb | Distal (>10kb) Multiome | 136 | |
| chr16:5,033,461–5,034,081 | 266.7 kb | Distal (>10kb) Multiome | 932 |
Genomic view of the ZNF500 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.