This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF43. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF43 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF43, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:20,285,651–20,286,726 | 1565.9 kb | Distal (>10kb) Multiome HiCAR | 95 | |
| chr19:20,660,950–20,661,849 | 1190.4 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr19:20,665,001–20,665,677 | 1186.7 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr19:21,328,840–21,329,770 | 522.7 kb | Distal (>10kb) Multiome HiCAR | 544 | |
| chr19:21,767,089–21,767,975 | 84.5 kb | Distal (>10kb) Multiome | 451 | |
| chr19:21,835,386–21,836,775 | 15.8 kb | Distal (>10kb) Multiome | 486 | |
| chr19:21,851,477–21,852,502 | 3 bp | At TSS Multiome | 414 | |
| chr19:21,856,706–21,857,377 | 4.7 kb | Proximal (<10kb) | 16 | |
| chr19:21,857,936–21,858,623 | 5.9 kb | Proximal (<10kb) | 8 | |
| chr19:23,686,411–23,687,441 | 1835.1 kb | Distal (>10kb) Multiome HiCAR | 490 | |
| chr19:23,762,593–23,763,893 | 1911.0 kb | Distal (>10kb) Multiome HiCAR | 429 |
Genomic view of the ZNF43 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.