Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF414. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF414 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF414, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:8,268,737–8,269,370 | 245.2 kb | Distal (>10kb) Multiome | 272 | |
| chr19:8,307,739–8,308,717 | 205.9 kb | Distal (>10kb) Multiome | 973 | |
| chr19:8,314,738–8,315,490 | 199.1 kb | Distal (>10kb) Multiome | 49 | |
| chr19:8,320,824–8,321,811 | 192.7 kb | Distal (>10kb) Multiome | 871 | |
| chr19:8,334,500–8,335,843 | 178.8 kb | Distal (>10kb) Multiome | 384 | |
| chr19:8,342,762–8,343,678 | 170.8 kb | Distal (>10kb) Multiome | 440 | |
| chr19:8,363,586–8,364,765 | 150.1 kb | Distal (>10kb) Multiome | 549 | |
| chr19:8,389,684–8,391,548 | 123.9 kb | Distal (>10kb) Multiome | 878 | |
| chr19:8,412,769–8,413,775 | 101.0 kb | Distal (>10kb) Multiome | 566 | |
| chr19:8,444,605–8,445,806 | 69.3 kb | Distal (>10kb) Multiome | 910 | |
| chr19:8,505,742–8,506,861 | 7.9 kb | Proximal (<10kb) Multiome | 739 | |
| chr19:8,511,414–8,512,588 | 2.1 kb | Proximal (<10kb) Multiome | 263 | |
| chr19:8,513,025–8,514,530 | 194 bp | At TSS Multiome | 825 | |
| chr19:8,525,196–8,527,085 | 11.6 kb | Distal (>10kb) Multiome | 783 | |
| chr19:8,580,484–8,581,056 | 66.8 kb | Distal (>10kb) Multiome | 535 | |
| chr19:8,591,781–8,593,224 | 78.3 kb | Distal (>10kb) Multiome | 389 | |
| chr19:8,609,061–8,609,913 | 95.3 kb | Distal (>10kb) Multiome | 432 | |
| chr19:8,610,265–8,610,915 | 96.7 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the ZNF414 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.