This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked cognitive disability, but a later study has called this finding into question (PMID:23871722).[provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for ZNF41. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF41 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF41, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,190,608–47,191,059 | 291.9 kb | Distal (>10kb) Multiome | 536 | |
| chrX:47,191,642–47,192,226 | 290.5 kb | Distal (>10kb) Multiome | 138 | |
| chrX:47,193,067–47,193,943 | 288.8 kb | Distal (>10kb) Multiome | 651 | |
| chrX:47,217,449–47,219,337 | 264.6 kb | Distal (>10kb) Multiome | 736 | |
| chrX:47,232,860–47,233,865 | 249.0 kb | Distal (>10kb) Multiome | 684 | |
| chrX:47,321,409–47,321,883 | 161.0 kb | Distal (>10kb) Multiome | 127 | |
| chrX:47,361,756–47,362,456 | 120.4 kb | Distal (>10kb) Multiome | 297 | |
| chrX:47,381,691–47,382,470 | 100.4 kb | Distal (>10kb) Multiome | 17 | |
| chrX:47,482,474–47,483,311 | 175 bp | At TSS Multiome | 573 | |
| chrX:47,523,425–47,523,870 | 41.0 kb | Distal (>10kb) Multiome | 403 | |
| chrX:47,556,126–47,556,602 | 73.7 kb | Distal (>10kb) Multiome | 278 | |
| chrX:47,560,759–47,561,636 | 78.6 kb | Distal (>10kb) Multiome | 638 | |
| chrX:47,619,457–47,620,174 | 137.3 kb | Distal (>10kb) Multiome | 643 | |
| chrX:47,623,578–47,624,031 | 141.3 kb | Distal (>10kb) Multiome | 183 | |
| chrX:47,650,269–47,651,363 | 168.2 kb | Distal (>10kb) Multiome | 552 | |
| chrX:47,658,568–47,659,484 | 176.4 kb | Distal (>10kb) Multiome | 753 |
Genomic view of the ZNF41 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.