Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF391. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF391 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF391, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:27,091,728–27,092,257 | 296.8 kb | Distal (>10kb) Multiome | 610 | |
| chr6:27,131,467–27,132,107 | 257.1 kb | Distal (>10kb) Multiome | 580 | |
| chr6:27,132,200–27,134,276 | 255.8 kb | Distal (>10kb) Multiome | 975 | |
| chr6:27,139,091–27,140,128 | 249.3 kb | Distal (>10kb) Multiome | 662 | |
| chr6:27,145,480–27,148,111 | 241.7 kb | Distal (>10kb) Multiome | 951 | |
| chr6:27,177,493–27,178,620 | 210.7 kb | Distal (>10kb) Multiome | 685 | |
| chr6:27,188,443–27,189,128 | 200.0 kb | Distal (>10kb) Multiome | 398 | |
| chr6:27,214,739–27,215,257 | 173.7 kb | Distal (>10kb) Multiome | 338 | |
| chr6:27,230,181–27,230,668 | 158.3 kb | Distal (>10kb) Multiome | 624 | |
| chr6:27,250,707–27,252,203 | 137.0 kb | Distal (>10kb) Multiome | 736 | |
| chr6:27,279,529–27,280,388 | 108.4 kb | Distal (>10kb) Multiome | 560 | |
| chr6:27,290,574–27,291,026 | 98.0 kb | Distal (>10kb) Multiome | 324 | |
| chr6:27,332,775–27,333,421 | 55.6 kb | Distal (>10kb) Multiome | 657 | |
| chr6:27,374,472–27,375,425 | 13.6 kb | Distal (>10kb) Multiome | 488 | |
| chr6:27,388,369–27,389,372 | 77 bp | At TSS Multiome | 997 | |
| chr6:27,472,233–27,473,587 | 84.3 kb | Distal (>10kb) Multiome | 1052 | |
| chr6:27,478,759–27,479,180 | 90.1 kb | Distal (>10kb) Multiome | 642 | |
| chr6:27,479,324–27,480,016 | 90.9 kb | Distal (>10kb) Multiome | 750 | |
| chr6:27,495,395–27,496,098 | 107.0 kb | Distal (>10kb) Multiome | 724 | |
| chr6:27,502,683–27,503,927 | 115.0 kb | Distal (>10kb) Multiome | 699 | |
| chr6:27,505,539–27,506,022 | 117.1 kb | Distal (>10kb) Multiome | 646 | |
| chr6:27,518,890–27,519,632 | 130.5 kb | Distal (>10kb) Multiome | 717 | |
| chr6:27,545,031–27,546,022 | 156.9 kb | Distal (>10kb) Multiome | 662 | |
| chr6:27,547,469–27,547,915 | 158.9 kb | Distal (>10kb) Multiome | 440 | |
| chr6:27,552,906–27,553,807 | 164.7 kb | Distal (>10kb) Multiome | 694 | |
| chr6:27,592,359–27,593,376 | 204.1 kb | Distal (>10kb) Multiome | 844 | |
| chr6:27,602,046–27,602,794 | 213.7 kb | Distal (>10kb) Multiome | 469 | |
| chr6:27,605,356–27,606,138 | 217.0 kb | Distal (>10kb) Multiome | 562 | |
| chr6:27,630,675–27,631,795 | 242.4 kb | Distal (>10kb) Multiome | 827 | |
| chr6:27,650,587–27,651,063 | 262.1 kb | Distal (>10kb) Multiome | 541 | |
| chr6:27,668,541–27,669,069 | 279.9 kb | Distal (>10kb) Multiome | 577 | |
| chr6:27,671,980–27,673,036 | 283.7 kb | Distal (>10kb) Multiome | 845 | |
| chr6:27,684,282–27,684,819 | 295.9 kb | Distal (>10kb) Multiome | 652 | |
| chr6:27,687,268–27,688,540 | 298.9 kb | Distal (>10kb) Multiome | 972 |
Genomic view of the ZNF391 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.