Enables sequence-specific double-stranded DNA binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF385D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF385D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF385D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:20,185,379–20,186,994 | 2186.3 kb | Distal (>10kb) Multiome HiCAR | 897 | |
| chr3:21,542,953–21,544,330 | 829.0 kb | Distal (>10kb) Multiome | 330 | |
| chr3:21,728,994–21,730,158 | 643.1 kb | Distal (>10kb) Multiome | 118 | |
| chr3:21,749,994–21,752,164 | 621.4 kb | Distal (>10kb) Multiome | 379 | |
| chr3:21,752,848–21,753,059 | 1.6 kb | Proximal (<10kb) | 127 | |
| chr3:22,371,296–22,373,412 | 120 bp | At TSS Multiome | 291 |
Genomic view of the ZNF385D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.