Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]
Transcription factors with Perturb-seq knockdown data for ZNF385A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF385A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF385A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:54,378,747–54,380,140 | 5.6 kb | Proximal (<10kb) | 649 | |
| chr12:54,385,548–54,386,072 | at TSS | At TSS | 79 | |
| chr12:54,390,265–54,391,699 | 4.5 kb | Proximal (<10kb) | 393 | |
| chr12:54,394,335–54,394,519 | 8.6 kb | Proximal (<10kb) | 221 | |
| chr12:54,399,371–54,399,784 | 8.1 kb | Proximal (<10kb) | 278 |
Genomic view of the ZNF385A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.