This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for ZNF334. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF334 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF334, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:46,268,041–46,268,560 | 245.3 kb | Distal (>10kb) Multiome | 82 | |
| chr20:46,307,134–46,307,979 | 206.3 kb | Distal (>10kb) Multiome | 455 | |
| chr20:46,308,245–46,308,857 | 204.9 kb | Distal (>10kb) Multiome | 287 | |
| chr20:46,363,898–46,364,657 | 149.2 kb | Distal (>10kb) Multiome | 983 | |
| chr20:46,405,903–46,407,320 | 107.0 kb | Distal (>10kb) Multiome | 946 | |
| chr20:46,459,001–46,459,476 | 54.3 kb | Distal (>10kb) Multiome | 157 | |
| chr20:46,513,244–46,513,752 | 4 bp | At TSS Multiome | 458 | |
| chr20:46,521,070–46,521,327 | 7.5 kb | Proximal (<10kb) | 243 | |
| chr20:46,562,567–46,563,148 | 49.3 kb | Distal (>10kb) Multiome | 483 | |
| chr20:46,583,359–46,584,278 | 70.2 kb | Distal (>10kb) Multiome | 196 | |
| chr20:46,648,981–46,649,761 | 135.7 kb | Distal (>10kb) Multiome | 275 | |
| chr20:46,651,152–46,651,711 | 137.9 kb | Distal (>10kb) Multiome | 558 | |
| chr20:46,688,904–46,689,939 | 176.0 kb | Distal (>10kb) Multiome HiCAR | 940 | |
| chr20:46,709,122–46,710,092 | 196.1 kb | Distal (>10kb) Multiome | 652 |
Genomic view of the ZNF334 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.