Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to glucose stimulus. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF236. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF236 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF236, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:76,619,324–76,620,729 | 202.3 kb | Distal (>10kb) Multiome | 340 | |
| chr18:76,801,725–76,802,542 | 20.4 kb | Distal (>10kb) Multiome | 431 | |
| chr18:76,821,727–76,823,983 | 108 bp | At TSS Multiome | 759 | |
| chr18:76,983,122–76,983,873 | 160.9 kb | Distal (>10kb) Multiome | 312 | |
| chr18:77,088,896–77,089,706 | 266.8 kb | Distal (>10kb) Multiome | 303 | |
| chr18:77,099,611–77,100,346 | 277.4 kb | Distal (>10kb) Multiome | 134 |
Genomic view of the ZNF236 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.