ZNF219

zinc finger protein 219

This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017]

Member of: DE-7 Developmental clusters: GC3

Biological processes 22 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)G protein-coupled receptor signaling pathway (GO:0007186)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)histamine receptor activity (GO:0004969)limb bud formation (GO:0060174)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of chondrocyte differentiation (GO:0032332)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)

Expression (TPM)

TFs regulating ZNF219 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF219. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF219 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF219

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF219, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:20,815,630–20,816,752	287.5 kb	Distal (>10kb) Multiome	75
chr14:20,820,324–20,820,826	283.0 kb	Distal (>10kb) Multiome	204
chr14:20,970,757–20,971,991	132.1 kb	Distal (>10kb) Multiome	745
chr14:20,989,595–20,990,562	113.7 kb	Distal (>10kb) Multiome	835
chr14:21,024,660–21,026,214	78.5 kb	Distal (>10kb) Multiome	768
chr14:21,069,280–21,071,963	32.0 kb	Distal (>10kb) Multiome	899
chr14:21,090,364–21,090,552	8.1 kb	Proximal (<10kb)	239
chr14:21,092,184–21,093,275	10.9 kb	Distal (>10kb) Multiome	774
chr14:21,094,184–21,094,833	9.1 kb	Proximal (<10kb) Multiome	210
chr14:21,097,193–21,098,877	5.1 kb	Proximal (<10kb) Multiome	469
chr14:21,103,222–21,104,876	365 bp	At TSS Multiome	1128
chr14:21,106,944–21,107,347	8.3 kb	Proximal (<10kb)	504
chr14:21,191,911–21,192,845	88.5 kb	Distal (>10kb) Multiome	463
chr14:21,268,822–21,270,154	166.1 kb	Distal (>10kb) Multiome	1029
chr14:21,308,204–21,309,328	205.3 kb	Distal (>10kb) Multiome	647
chr14:21,383,896–21,384,850	280.7 kb	Distal (>10kb) Multiome	931

Genome Browser

Genomic view of the ZNF219 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.