This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for ZNF154. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF154 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF154, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,410,944–57,411,658 | 298.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 273.8 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 231.6 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 221.4 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 209.3 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 181.8 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 149.4 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 130.2 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 125.2 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 109.3 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 95.0 kb | Distal (>10kb) Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 76.0 kb | Distal (>10kb) Multiome | 652 | |
| chr19:57,681,556–57,682,393 | 27.3 kb | Distal (>10kb) Multiome | 724 | |
| chr19:57,708,682–57,709,450 | 8 bp | At TSS Multiome | 199 | |
| chr19:57,709,699–57,709,852 | 495 bp | At TSS | 3 | |
| chr19:57,727,326–57,727,941 | 18.4 kb | Distal (>10kb) Multiome | 400 | |
| chr19:57,746,610–57,747,111 | 37.6 kb | Distal (>10kb) Multiome | 625 | |
| chr19:57,769,422–57,770,058 | 60.5 kb | Distal (>10kb) Multiome | 509 | |
| chr19:57,803,547–57,804,316 | 94.7 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 95.9 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 101.6 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 105.8 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 110.4 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 121.1 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 140.6 kb | Distal (>10kb) Multiome | 291 | |
| chr19:57,887,264–57,887,897 | 178.4 kb | Distal (>10kb) Multiome | 47 | |
| chr19:57,888,389–57,889,457 | 179.8 kb | Distal (>10kb) Multiome | 322 | |
| chr19:57,916,199–57,917,124 | 207.5 kb | Distal (>10kb) Multiome | 535 | |
| chr19:57,934,907–57,935,617 | 226.2 kb | Distal (>10kb) Multiome | 259 | |
| chr19:57,947,388–57,948,012 | 238.6 kb | Distal (>10kb) Multiome | 675 | |
| chr19:58,002,336–58,003,368 | 293.6 kb | Distal (>10kb) Multiome | 830 | |
| chr19:58,150,278–58,150,941 | 441.5 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr19:58,154,448–58,155,527 | 445.9 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the ZNF154 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.