Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZMAT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZMAT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZMAT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:140,400,395–140,402,925 | 298.9 kb | Distal (>10kb) Multiome | 1129 | |
| chr5:140,546,917–140,548,500 | 152.8 kb | Distal (>10kb) Multiome | 784 | |
| chr5:140,556,971–140,557,959 | 143.0 kb | Distal (>10kb) Multiome | 886 | |
| chr5:140,564,055–140,565,123 | 135.8 kb | Distal (>10kb) Multiome | 827 | |
| chr5:140,639,043–140,640,146 | 61.0 kb | Distal (>10kb) Multiome | 898 | |
| chr5:140,647,175–140,648,159 | 52.7 kb | Distal (>10kb) Multiome | 863 | |
| chr5:140,664,368–140,665,161 | 35.7 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,673,200–140,673,759 | 26.9 kb | Distal (>10kb) Multiome | 144 | |
| chr5:140,691,053–140,691,933 | 8.9 kb | Proximal (<10kb) Multiome | 924 | |
| chr5:140,696,939–140,697,394 | 3.1 kb | Proximal (<10kb) | 21 | |
| chr5:140,699,981–140,700,742 | 81 bp | At TSS Multiome | 607 | |
| chr5:140,710,433–140,711,671 | 10.6 kb | Distal (>10kb) Multiome | 856 | |
| chr5:140,718,340–140,718,978 | 18.2 kb | Distal (>10kb) Multiome | 763 | |
| chr5:140,725,570–140,726,438 | 25.5 kb | Distal (>10kb) Multiome | 719 | |
| chr5:140,925,961–140,927,592 | 226.1 kb | Distal (>10kb) Multiome | 419 | |
| chr5:140,965,919–140,967,712 | 266.2 kb | Distal (>10kb) Multiome | 368 |
Genomic view of the ZMAT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.