Transcription factors with Perturb-seq knockdown data for ZKSCAN7-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZKSCAN7-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZKSCAN7-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:44,337,649–44,339,009 | 286.4 kb | Distal (>10kb) Multiome | 1024 | |
| chr3:44,477,346–44,478,014 | 147.3 kb | Distal (>10kb) Multiome | 561 | |
| chr3:44,510,368–44,511,080 | 114.2 kb | Distal (>10kb) Multiome | 607 | |
| chr3:44,554,965–44,555,488 | 69.8 kb | Distal (>10kb) Multiome | 434 | |
| chr3:44,584,465–44,585,362 | 40.1 kb | Distal (>10kb) Multiome | 388 | |
| chr3:44,624,770–44,625,563 | 123 bp | At TSS Multiome | 686 | |
| chr3:44,648,515–44,649,232 | 23.8 kb | Distal (>10kb) Multiome | 554 | |
| chr3:44,676,273–44,676,692 | 9.0 kb | Proximal (<10kb) | 14 | |
| chr3:44,685,378–44,685,791 | at TSS | At TSS | 288 | |
| chr3:44,729,240–44,729,901 | 104.6 kb | Distal (>10kb) Multiome | 780 | |
| chr3:44,761,326–44,762,300 | 136.8 kb | Distal (>10kb) Multiome | 966 | |
| chr3:44,861,375–44,862,600 | 236.9 kb | Distal (>10kb) Multiome | 765 | |
| chr3:44,975,358–44,976,703 | 351.2 kb | Distal (>10kb) Multiome | 732 |
Genomic view of the ZKSCAN7-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.