Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZIK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZIK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZIK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,320,108–57,321,075 | 263.2 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 232.4 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 220.2 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 193.8 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 172.5 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 148.2 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 106.0 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 95.8 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 83.7 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 56.2 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 23.8 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 4.6 kb | Proximal (<10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 396 bp | At TSS Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 16.3 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 30.6 kb | Distal (>10kb) Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 49.6 kb | Distal (>10kb) Multiome | 652 | |
| chr19:57,681,556–57,682,393 | 98.3 kb | Distal (>10kb) Multiome | 724 | |
| chr19:57,708,682–57,709,450 | 125.6 kb | Distal (>10kb) Multiome | 199 | |
| chr19:57,727,326–57,727,941 | 144.0 kb | Distal (>10kb) Multiome | 400 | |
| chr19:57,746,610–57,747,111 | 163.2 kb | Distal (>10kb) Multiome | 625 | |
| chr19:57,769,422–57,770,058 | 186.0 kb | Distal (>10kb) Multiome | 509 | |
| chr19:57,803,547–57,804,316 | 220.3 kb | Distal (>10kb) Multiome | 206 | |
| chr19:57,804,773–57,805,214 | 221.5 kb | Distal (>10kb) Multiome | 37 | |
| chr19:57,810,480–57,811,177 | 227.2 kb | Distal (>10kb) Multiome | 180 | |
| chr19:57,814,439–57,815,270 | 231.4 kb | Distal (>10kb) Multiome | 692 | |
| chr19:57,819,268–57,819,991 | 236.0 kb | Distal (>10kb) Multiome | 734 | |
| chr19:57,829,187–57,830,712 | 246.7 kb | Distal (>10kb) Multiome | 321 | |
| chr19:57,849,421–57,850,221 | 266.2 kb | Distal (>10kb) Multiome | 291 | |
| chr19:58,150,278–58,150,941 | 567.1 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr19:58,154,448–58,155,527 | 571.5 kb | Distal (>10kb) Multiome HiCAR | 802 |
Genomic view of the ZIK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.