This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZHX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZHX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZHX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:41,028,014–41,029,610 | 289.0 kb | Distal (>10kb) Multiome | 977 | |
| chr20:41,135,300–41,135,808 | 182.2 kb | Distal (>10kb) Multiome | 451 | |
| chr20:41,136,345–41,138,443 | 180.4 kb | Distal (>10kb) Multiome | 1007 | |
| chr20:41,249,859–41,250,320 | 67.6 kb | Distal (>10kb) Multiome | 183 | |
| chr20:41,316,979–41,318,388 | 86 bp | At TSS Multiome | 894 | |
| chr20:41,339,588–41,341,431 | 23.0 kb | Distal (>10kb) Multiome | 904 | |
| chr20:41,365,890–41,367,375 | 49.2 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the ZHX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.