The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZHX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZHX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZHX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:122,638,668–122,639,514 | 142.6 kb | Distal (>10kb) Multiome | 424 | |
| chr8:122,686,468–122,687,541 | 94.6 kb | Distal (>10kb) Multiome | 263 | |
| chr8:122,780,039–122,780,999 | 1.3 kb | Proximal (<10kb) Multiome | 860 | |
| chr8:122,781,087–122,783,557 | 1.5 kb | Proximal (<10kb) Multiome | 793 | |
| chr8:122,787,578–122,788,020 | 5.9 kb | Proximal (<10kb) | 130 | |
| chr8:122,837,253–122,838,328 | 56.3 kb | Distal (>10kb) Multiome | 291 | |
| chr8:123,041,536–123,042,890 | 260.6 kb | Distal (>10kb) Multiome | 925 | |
| chr8:123,065,582–123,066,386 | 284.4 kb | Distal (>10kb) Multiome | 354 | |
| chr8:123,072,367–123,073,561 | 291.0 kb | Distal (>10kb) Multiome | 858 |
Genomic view of the ZHX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.