This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Transcription factors with Perturb-seq knockdown data for ZFYVE16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFYVE16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFYVE16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:80,111,066–80,112,197 | 296.5 kb | Distal (>10kb) Multiome | 104 | |
| chr5:80,141,245–80,141,718 | 266.5 kb | Distal (>10kb) Multiome | 179 | |
| chr5:80,180,501–80,181,544 | 227.0 kb | Distal (>10kb) Multiome | 195 | |
| chr5:80,183,069–80,185,467 | 224.6 kb | Distal (>10kb) Multiome | 646 | |
| chr5:80,185,568–80,186,143 | 222.2 kb | Distal (>10kb) Multiome | 70 | |
| chr5:80,204,750–80,205,627 | 203.0 kb | Distal (>10kb) Multiome | 594 | |
| chr5:80,255,259–80,256,736 | 151.9 kb | Distal (>10kb) Multiome | 873 | |
| chr5:80,257,220–80,257,979 | 150.3 kb | Distal (>10kb) Multiome | 496 | |
| chr5:80,407,421–80,408,673 | 58 bp | At TSS Multiome | 954 | |
| chr5:80,487,503–80,488,829 | 80.2 kb | Distal (>10kb) Multiome | 871 | |
| chr5:80,554,442–80,555,055 | 146.8 kb | Distal (>10kb) Multiome | 148 | |
| chr5:80,568,978–80,570,765 | 162.3 kb | Distal (>10kb) Multiome | 431 | |
| chr5:80,654,076–80,655,416 | 246.9 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the ZFYVE16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.