ZFTRAF1

zinc finger TRAF-type and ring finger containing 1 | CHRP, KIAA0496, MGC13010, CYHR1

Predicted to enable zinc ion binding activity. Predicted to be located in nuclear envelope and perinuclear region of cytoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6

Biological processes 4 terms

cytoplasm (GO:0005737)perinuclear region of cytoplasm (GO:0048471)protein binding (GO:0005515)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating ZFTRAF1 0 TFs

Transcription factors with Perturb-seq knockdown data for ZFTRAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFTRAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZFTRAF1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFTRAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:144,266,293–144,267,098	196.4 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	171.4 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	146.7 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	136.0 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	130.9 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	126.0 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	108.3 kb	Distal (>10kb) Multiome	280
chr8:144,358,142–144,359,070	104.3 kb	Distal (>10kb) Multiome	719
chr8:144,369,349–144,369,916	93.2 kb	Distal (>10kb) Multiome	204
chr8:144,372,497–144,372,883	90.2 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	88.9 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	53.4 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	34.3 kb	Distal (>10kb) Multiome	1000
chr8:144,443,691–144,445,047	18.5 kb	Distal (>10kb) Multiome	743
chr8:144,462,568–144,463,422	47 bp	At TSS Multiome	548
chr8:144,463,885–144,468,178	2.9 kb	Proximal (<10kb) Multiome	910
chr8:144,471,960–144,474,391	9.7 kb	Proximal (<10kb) Multiome	482
chr8:144,474,517–144,476,543	13.0 kb	Distal (>10kb) Multiome	321
chr8:144,477,277–144,478,749	15.1 kb	Distal (>10kb) Multiome	679
chr8:144,478,851–144,479,509	16.4 kb	Distal (>10kb) Multiome	392
chr8:144,483,979–144,484,843	21.5 kb	Distal (>10kb) Multiome	125
chr8:144,495,748–144,496,431	33.2 kb	Distal (>10kb) Multiome	131
chr8:144,500,182–144,501,505	38.1 kb	Distal (>10kb) Multiome HiCAR	484
chr8:144,507,995–144,510,268	46.0 kb	Distal (>10kb) Multiome HiCAR	1067
chr8:144,517,168–144,518,442	55.0 kb	Distal (>10kb) Multiome HiCAR	637
chr8:144,521,935–144,523,450	59.6 kb	Distal (>10kb) Multiome	663
chr8:144,524,105–144,525,099	61.8 kb	Distal (>10kb) Multiome	264
chr8:144,526,399–144,529,305	64.2 kb	Distal (>10kb) Multiome	934
chr8:144,529,455–144,530,630	67.3 kb	Distal (>10kb) Multiome	284
chr8:144,580,290–144,581,657	117.9 kb	Distal (>10kb) Multiome	271
chr8:144,672,507–144,672,989	210.0 kb	Distal (>10kb) Multiome	150
chr8:144,684,108–144,686,340	221.5 kb	Distal (>10kb) Multiome	862
chr8:144,755,078–144,755,956	292.7 kb	Distal (>10kb) Multiome	769
chr8:144,791,751–144,793,221	329.6 kb	Distal (>10kb) Multiome HiCAR	899
chr8:144,798,389–144,799,501	336.0 kb	Distal (>10kb) Multiome HiCAR	832

Genome Browser

Genomic view of the ZFTRAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.