This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Transcription factors with Perturb-seq knockdown data for ZFP90. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP90 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP90, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:68,235,016–68,238,254 | 293.9 kb | Distal (>10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 290.1 kb | Distal (>10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 284.8 kb | Distal (>10kb) Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 265.6 kb | Distal (>10kb) Multiome | 876 | |
| chr16:68,310,451–68,311,505 | 219.1 kb | Distal (>10kb) Multiome | 1061 | |
| chr16:68,328,654–68,329,423 | 201.3 kb | Distal (>10kb) Multiome | 438 | |
| chr16:68,420,400–68,420,906 | 109.5 kb | Distal (>10kb) Multiome | 58 | |
| chr16:68,447,981–68,449,250 | 81.5 kb | Distal (>10kb) Multiome | 795 | |
| chr16:68,520,489–68,521,019 | 9.3 kb | Proximal (<10kb) Multiome | 602 | |
| chr16:68,528,418–68,529,128 | 1.4 kb | Proximal (<10kb) Multiome | 552 | |
| chr16:68,529,733–68,530,671 | 102 bp | At TSS Multiome | 831 | |
| chr16:68,538,873–68,540,027 | 9.2 kb | Proximal (<10kb) Multiome | 764 | |
| chr16:68,642,503–68,643,044 | 112.7 kb | Distal (>10kb) Multiome | 288 | |
| chr16:68,644,824–68,646,405 | 115.2 kb | Distal (>10kb) Multiome | 442 | |
| chr16:68,736,847–68,738,492 | 207.2 kb | Distal (>10kb) Multiome | 537 | |
| chr16:68,778,480–68,779,271 | 248.9 kb | Distal (>10kb) Multiome | 248 | |
| chr16:69,105,371–69,107,181 | 576.2 kb | Distal (>10kb) Multiome HiCAR | 631 |
Genomic view of the ZFP90 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.