This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for ZFP36L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP36L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP36L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:67,934,038–67,934,596 | 858.8 kb | Distal (>10kb) Multiome HiCAR | 380 | |
| chr14:68,628,283–68,629,329 | 164.6 kb | Distal (>10kb) Multiome | 311 | |
| chr14:68,762,791–68,763,528 | 29.9 kb | Distal (>10kb) Multiome | 389 | |
| chr14:68,788,943–68,789,202 | 3.9 kb | Proximal (<10kb) | 369 | |
| chr14:68,790,871–68,793,970 | 250 bp | At TSS Multiome | 866 | |
| chr14:68,794,111–68,794,734 | 1.0 kb | Proximal (<10kb) | 674 | |
| chr14:68,794,853–68,797,758 | 3.0 kb | Proximal (<10kb) Multiome | 1023 | |
| chr14:68,816,186–68,816,983 | 23.6 kb | Distal (>10kb) Multiome | 816 | |
| chr14:68,862,998–68,863,526 | 70.2 kb | Distal (>10kb) Multiome | 296 | |
| chr14:68,937,585–68,939,538 | 145.6 kb | Distal (>10kb) Multiome | 580 | |
| chr14:68,977,829–68,980,593 | 186.4 kb | Distal (>10kb) Multiome | 919 | |
| chr14:69,050,256–69,051,065 | 257.6 kb | Distal (>10kb) Multiome | 105 |
Genomic view of the ZFP36L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.