This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for ZFP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:74,866,003–74,866,478 | 282.4 kb | Distal (>10kb) Multiome | 95 | |
| chr16:74,984,580–74,985,562 | 163.4 kb | Distal (>10kb) Multiome | 877 | |
| chr16:74,998,533–75,000,404 | 149.6 kb | Distal (>10kb) Multiome | 884 | |
| chr16:75,110,910–75,111,744 | 37.2 kb | Distal (>10kb) Multiome | 720 | |
| chr16:75,148,292–75,149,298 | 86 bp | At TSS Multiome | 970 | |
| chr16:75,250,387–75,252,500 | 103.1 kb | Distal (>10kb) Multiome | 811 | |
| chr16:75,265,114–75,266,526 | 117.5 kb | Distal (>10kb) Multiome | 798 | |
| chr16:75,432,825–75,434,426 | 285.0 kb | Distal (>10kb) Multiome | 1143 |
Genomic view of the ZFP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.