This gene represents a snoRNA host gene that produces a non-coding RNA. Increased expression or amplification of this locus is associated with cancer progression and metastasis. This transcript regulates expression of genes involved in differentiation. It may act a molecular sponge for microRNAs. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2017]
Transcription factors with Perturb-seq knockdown data for ZFAS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:49,045,736–49,047,213 | 232.1 kb | Distal (>10kb) Multiome | 1069 | |
| chr20:49,187,732–49,189,017 | 90.2 kb | Distal (>10kb) Multiome | 893 | |
| chr20:49,218,926–49,220,026 | 59.3 kb | Distal (>10kb) Multiome | 836 | |
| chr20:49,277,517–49,279,612 | 271 bp | At TSS Multiome | 1199 | |
| chr20:49,281,046–49,281,491 | 2.4 kb | Proximal (<10kb) | 451 | |
| chr20:49,289,765–49,291,410 | 11.7 kb | Distal (>10kb) Multiome | 436 | |
| chr20:49,482,537–49,483,070 | 204.3 kb | Distal (>10kb) Multiome | 732 | |
| chr20:49,483,315–49,484,620 | 205.7 kb | Distal (>10kb) Multiome | 684 | |
| chr20:49,567,583–49,569,009 | 289.6 kb | Distal (>10kb) Multiome | 251 |
Genomic view of the ZFAS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.