Predicted to enable magnesium ion transmembrane transporter activity and palmitoyltransferase activity. Involved in positive regulation of canonical NF-kappaB signal transduction. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:18,900,169–18,900,999 | 216.6 kb | Distal (>10kb) Multiome | 195 | |
| chr11:18,981,798–18,982,593 | 134.9 kb | Distal (>10kb) Multiome | 73 | |
| chr11:19,116,453–19,117,908 | 21 bp | At TSS Multiome | 722 | |
| chr11:19,240,390–19,242,958 | 123.9 kb | Distal (>10kb) Multiome | 757 | |
| chr11:19,345,021–19,345,985 | 228.2 kb | Distal (>10kb) Multiome | 233 |
Genomic view of the ZDHHC13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.