Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:62,324,436–62,326,421 | 197.8 kb | Distal (>10kb) Multiome | 552 | |
| chr18:62,384,424–62,385,314 | 138.1 kb | Distal (>10kb) Multiome | 240 | |
| chr18:62,522,181–62,525,120 | 38 bp | At TSS Multiome | 1028 | |
| chr18:62,526,182–62,527,164 | 3.7 kb | Proximal (<10kb) Multiome | 853 | |
| chr18:62,596,005–62,597,172 | 73.5 kb | Distal (>10kb) Multiome | 194 | |
| chr18:62,714,581–62,717,590 | 192.2 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the ZCCHC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.