This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ZC3HC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3HC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3HC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:129,775,743–129,776,961 | 274.8 kb | Distal (>10kb) Multiome | 77 | |
| chr7:129,778,637–129,782,868 | 271.1 kb | Distal (>10kb) Multiome | 821 | |
| chr7:129,824,642–129,826,481 | 225.5 kb | Distal (>10kb) Multiome | 809 | |
| chr7:129,829,901–129,830,704 | 221.1 kb | Distal (>10kb) Multiome | 440 | |
| chr7:129,914,750–129,915,367 | 136.2 kb | Distal (>10kb) Multiome | 82 | |
| chr7:129,948,898–129,950,017 | 102.2 kb | Distal (>10kb) Multiome | 747 | |
| chr7:129,952,295–129,953,395 | 98.4 kb | Distal (>10kb) Multiome | 834 | |
| chr7:130,051,085–130,051,538 | at TSS | At TSS | 848 | |
| chr7:130,069,977–130,071,012 | 19.0 kb | Distal (>10kb) Multiome | 873 | |
| chr7:130,140,676–130,141,967 | 90.2 kb | Distal (>10kb) Multiome | 371 | |
| chr7:130,204,919–130,205,826 | 154.1 kb | Distal (>10kb) Multiome | 874 | |
| chr7:130,272,868–130,273,649 | 222.0 kb | Distal (>10kb) Multiome | 220 |
Genomic view of the ZC3HC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.