This gene encodes a CCCH-type zinc finger protein. This antiviral protein inhibits viral replication by recruiting cellular RNA degradation machineries to degrade viral mRNAs. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses, including Ebola virus, HIV and SARS-CoV-2 (which causes COVID-19). [provided by RefSeq, Sep 2021]
Transcription factors with Perturb-seq knockdown data for ZC3HAV1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3HAV1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3HAV1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:138,980,951–138,982,350 | 128.1 kb | Distal (>10kb) Multiome | 525 | |
| chr7:139,034,996–139,036,579 | 73.7 kb | Distal (>10kb) Multiome | 626 | |
| chr7:139,090,840–139,094,844 | 16.0 kb | Distal (>10kb) Multiome | 732 | |
| chr7:139,108,547–139,110,090 | 49 bp | At TSS Multiome | 920 | |
| chr7:139,118,901–139,119,566 | 9.5 kb | Proximal (<10kb) | 424 | |
| chr7:139,124,120–139,124,640 | 14.7 kb | Distal (>10kb) Multiome | 304 | |
| chr7:139,133,422–139,134,016 | 24.0 kb | Distal (>10kb) Multiome | 936 | |
| chr7:139,230,473–139,232,505 | 121.4 kb | Distal (>10kb) Multiome | 971 | |
| chr7:139,339,925–139,342,077 | 230.7 kb | Distal (>10kb) Multiome | 1259 | |
| chr7:139,359,044–139,360,936 | 250.7 kb | Distal (>10kb) Multiome | 1134 |
Genomic view of the ZC3HAV1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.