The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for ZC3H14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:88,322,020–88,324,446 | 239.4 kb | Distal (>10kb) Multiome | 373 | |
| chr14:88,364,579–88,365,430 | 198.0 kb | Distal (>10kb) Multiome | 118 | |
| chr14:88,385,143–88,386,368 | 177.3 kb | Distal (>10kb) Multiome | 743 | |
| chr14:88,551,095–88,552,499 | 11.4 kb | Distal (>10kb) Multiome | 512 | |
| chr14:88,554,467–88,555,337 | 8.1 kb | Proximal (<10kb) Multiome | 594 | |
| chr14:88,562,461–88,563,844 | 161 bp | At TSS Multiome | 904 | |
| chr14:88,682,305–88,683,364 | 119.7 kb | Distal (>10kb) Multiome | 210 | |
| chr14:88,791,992–88,793,502 | 229.9 kb | Distal (>10kb) Multiome | 611 | |
| chr14:88,824,077–88,825,117 | 261.6 kb | Distal (>10kb) Multiome | 798 | |
| chr14:89,011,860–89,013,394 | 449.3 kb | Distal (>10kb) Multiome HiCAR | 405 |
Genomic view of the ZC3H14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.