Enables DNA-binding transcription factor binding activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Located in cytosol; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZBTB49. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB49 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB49, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:4,048,067–4,048,621 | 241.9 kb | Distal (>10kb) Multiome | 77 | |
| chr4:4,107,312–4,107,787 | 182.6 kb | Distal (>10kb) Multiome | 107 | |
| chr4:4,142,740–4,143,168 | 147.3 kb | Distal (>10kb) Multiome | 52 | |
| chr4:4,247,950–4,248,717 | 42.0 kb | Distal (>10kb) Multiome | 853 | |
| chr4:4,289,645–4,290,743 | 39 bp | At TSS Multiome | 779 | |
| chr4:4,386,227–4,387,401 | 96.3 kb | Distal (>10kb) Multiome | 247 | |
| chr4:4,541,695–4,542,519 | 251.8 kb | Distal (>10kb) Multiome | 1129 | |
| chr4:4,574,736–4,575,902 | 285.2 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the ZBTB49 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.