ZBTB4
zinc finger and BTB domain containing 4 | KAISO-L1, KIAA1538, ZNF903

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleotide binding activity; and protein homodimerization activity. Involved in DNA damage response and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4 Developmental clusters: GC7
Biological processes 22 terms
DNA damage response (GO:0006974)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromosome (GO:0005694)methyl-CpG binding (GO:0008327)methyl-CpG binding (GO:0008327)methyl-CpNpG binding (GO:0010428)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein kinase binding (GO:0019901)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)sequence-specific DNA binding (GO:0043565)
Expression (TPM)
ZBTB4 — as a Regulated Gene

TFs regulating ZBTB4 0 TFs

Transcription factors with Perturb-seq knockdown data for ZBTB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBTB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ZBTB4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBTB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:7,204,820–7,205,551 279.1 kb Distal (>10kb) Multiome 364
chr17:7,207,943–7,208,476 276.0 kb Distal (>10kb) Multiome 91
chr17:7,213,858–7,216,461 269.8 kb Distal (>10kb) Multiome 737
chr17:7,219,603–7,220,515 264.3 kb Distal (>10kb) Multiome 793
chr17:7,233,847–7,235,210 249.7 kb Distal (>10kb) Multiome 1020
chr17:7,237,531–7,238,757 246.3 kb Distal (>10kb) Multiome 502
chr17:7,238,867–7,240,155 244.6 kb Distal (>10kb) Multiome 783
chr17:7,241,494–7,243,462 241.2 kb Distal (>10kb) Multiome 1037
chr17:7,251,263–7,252,962 232.1 kb Distal (>10kb) Multiome 985
chr17:7,260,746–7,263,748 221.7 kb Distal (>10kb) Multiome 639
chr17:7,280,161–7,282,555 202.6 kb Distal (>10kb) Multiome 841
chr17:7,293,901–7,295,189 189.5 kb Distal (>10kb) Multiome 443
chr17:7,296,224–7,296,683 187.7 kb Distal (>10kb) Multiome 688
chr17:7,306,788–7,309,027 176.9 kb Distal (>10kb) Multiome 896
chr17:7,314,722–7,315,725 168.9 kb Distal (>10kb) Multiome 843
chr17:7,328,881–7,330,972 154.8 kb Distal (>10kb) Multiome 809
chr17:7,349,378–7,350,590 134.0 kb Distal (>10kb) Multiome 414
chr17:7,351,208–7,352,575 132.2 kb Distal (>10kb) Multiome 857
chr17:7,356,082–7,356,523 128.0 kb Distal (>10kb) Multiome 485
chr17:7,383,791–7,384,537 100.0 kb Distal (>10kb) Multiome 218
chr17:7,393,924–7,395,223 89.6 kb Distal (>10kb) Multiome 744
chr17:7,403,290–7,405,695 79.9 kb Distal (>10kb) Multiome 838
chr17:7,435,167–7,437,681 47.2 kb Distal (>10kb) Multiome 828
chr17:7,437,892–7,438,555 46.0 kb Distal (>10kb) Multiome 224
chr17:7,440,048–7,441,211 43.6 kb Distal (>10kb) Multiome 487
chr17:7,444,968–7,446,142 38.7 kb Distal (>10kb) Multiome 632
chr17:7,455,450–7,456,019 28.6 kb Distal (>10kb) Multiome 414
chr17:7,478,839–7,480,126 4.7 kb Proximal (<10kb) Multiome 574
chr17:7,483,139–7,485,576 195 bp At TSS Multiome 1156
chr17:7,548,693–7,549,285 64.7 kb Distal (>10kb) Multiome 387
chr17:7,560,249–7,562,536 77.7 kb Distal (>10kb) Multiome 759
chr17:7,572,039–7,574,418 89.6 kb Distal (>10kb) Multiome 1071
chr17:7,579,018–7,579,876 95.2 kb Distal (>10kb) Multiome 844
chr17:7,583,063–7,584,547 99.5 kb Distal (>10kb) Multiome 921
chr17:7,588,871–7,590,534 105.9 kb Distal (>10kb) Multiome 319
chr17:7,614,065–7,615,780 130.8 kb Distal (>10kb) Multiome 708
chr17:7,627,090–7,628,247 143.6 kb Distal (>10kb) Multiome 712
chr17:7,650,010–7,652,127 166.5 kb Distal (>10kb) Multiome 467
chr17:7,685,876–7,686,907 202.0 kb Distal (>10kb) Multiome 765
chr17:7,687,214–7,687,777 203.2 kb Distal (>10kb) Multiome 710
chr17:7,687,867–7,688,863 204.1 kb Distal (>10kb) Multiome 700
chr17:7,703,383–7,703,975 219.4 kb Distal (>10kb) Multiome 141
chr17:7,704,799–7,705,590 220.9 kb Distal (>10kb) Multiome 325
chr17:7,716,832–7,717,983 233.1 kb Distal (>10kb) Multiome 759

Genome Browser

Genomic view of the ZBTB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:7,194,820 – 7,727,983
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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