Transcription factors with Perturb-seq knockdown data for ZBED3-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBED3-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBED3-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:76,789,270–76,790,249 | 296.8 kb | Distal (>10kb) Multiome | 123 | |
| chr5:76,808,093–76,808,802 | 278.3 kb | Distal (>10kb) Multiome | 237 | |
| chr5:76,818,476–76,819,940 | 267.8 kb | Distal (>10kb) Multiome | 686 | |
| chr5:76,873,943–76,874,791 | 212.3 kb | Distal (>10kb) Multiome | 261 | |
| chr5:76,953,306–76,954,445 | 133.0 kb | Distal (>10kb) Multiome | 235 | |
| chr5:77,030,193–77,031,058 | 56.3 kb | Distal (>10kb) Multiome | 903 | |
| chr5:77,076,843–77,078,059 | 9.1 kb | Proximal (<10kb) Multiome | 396 | |
| chr5:77,086,556–77,087,540 | 177 bp | At TSS Multiome | 768 | |
| chr5:77,210,182–77,211,717 | 123.7 kb | Distal (>10kb) Multiome | 287 | |
| chr5:77,231,266–77,232,033 | 145.0 kb | Distal (>10kb) Multiome | 69 |
Genomic view of the ZBED3-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.