This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for YWHAG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:76,073,173–76,073,663 | 285.5 kb | Distal (>10kb) Multiome | 100 | |
| chr7:76,163,449–76,164,544 | 195.0 kb | Distal (>10kb) Multiome | 132 | |
| chr7:76,166,338–76,167,166 | 192.3 kb | Distal (>10kb) Multiome | 644 | |
| chr7:76,177,965–76,178,641 | 180.7 kb | Distal (>10kb) Multiome | 670 | |
| chr7:76,201,356–76,202,307 | 157.2 kb | Distal (>10kb) Multiome | 937 | |
| chr7:76,234,695–76,235,681 | 123.7 kb | Distal (>10kb) Multiome | 329 | |
| chr7:76,259,707–76,261,052 | 98.6 kb | Distal (>10kb) Multiome | 332 | |
| chr7:76,267,044–76,267,853 | 91.6 kb | Distal (>10kb) Multiome | 211 | |
| chr7:76,282,299–76,283,220 | 76.3 kb | Distal (>10kb) Multiome | 237 | |
| chr7:76,291,428–76,292,275 | 67.1 kb | Distal (>10kb) Multiome | 767 | |
| chr7:76,302,207–76,304,173 | 56.5 kb | Distal (>10kb) Multiome | 943 | |
| chr7:76,314,028–76,314,686 | 44.6 kb | Distal (>10kb) Multiome | 715 | |
| chr7:76,317,523–76,319,173 | 40.8 kb | Distal (>10kb) Multiome | 840 | |
| chr7:76,358,237–76,359,989 | 300 bp | At TSS Multiome | 1036 | |
| chr7:76,379,650–76,380,602 | 21.1 kb | Distal (>10kb) Multiome | 853 | |
| chr7:76,392,882–76,394,121 | 34.3 kb | Distal (>10kb) Multiome | 932 | |
| chr7:76,395,928–76,396,741 | 37.2 kb | Distal (>10kb) Multiome | 152 | |
| chr7:76,397,187–76,397,970 | 38.6 kb | Distal (>10kb) Multiome | 496 | |
| chr7:76,409,261–76,409,956 | 50.8 kb | Distal (>10kb) Multiome | 281 | |
| chr7:76,510,075–76,510,721 | 151.4 kb | Distal (>10kb) Multiome | 201 | |
| chr7:76,548,975–76,549,826 | 190.3 kb | Distal (>10kb) Multiome | 505 |
Genomic view of the YWHAG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.