Enables N6-methyladenosine-containing RNA reader activity and RNA binding activity. Involved in gene expression and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YTHDC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YTHDC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YTHDC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:68,281,444–68,282,662 | 68.0 kb | Distal (>10kb) Multiome HiCAR | 168 | |
| chr4:68,342,164–68,342,449 | 7.3 kb | Proximal (<10kb) | 17 | |
| chr4:68,349,345–68,350,702 | 61 bp | At TSS Multiome | 948 | |
| chr4:68,367,612–68,368,369 | 17.9 kb | Distal (>10kb) Multiome HiCAR | 161 | |
| chr4:68,373,452–68,373,931 | 23.7 kb | Distal (>10kb) Multiome | 134 | |
| chr4:68,375,788–68,376,579 | 26.2 kb | Distal (>10kb) Multiome | 197 | |
| chr4:68,403,598–68,408,126 | 57.4 kb | Distal (>10kb) Multiome HiCAR | 393 |
Genomic view of the YTHDC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.