The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for YEATS4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YEATS4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YEATS4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:69,170,145–69,170,803 | 189.3 kb | Distal (>10kb) Multiome | 33 | |
| chr12:69,171,748–69,172,291 | 187.7 kb | Distal (>10kb) Multiome | 92 | |
| chr12:69,238,925–69,240,549 | 120.2 kb | Distal (>10kb) Multiome | 828 | |
| chr12:69,330,668–69,333,363 | 27.0 kb | Distal (>10kb) Multiome | 710 | |
| chr12:69,357,526–69,357,760 | 2.0 kb | Proximal (<10kb) | 312 | |
| chr12:69,359,411–69,360,582 | 208 bp | At TSS Multiome | 990 | |
| chr12:69,470,012–69,471,069 | 110.6 kb | Distal (>10kb) Multiome | 831 | |
| chr12:69,585,221–69,586,062 | 225.8 kb | Distal (>10kb) Multiome HiCAR | 1005 |
Genomic view of the YEATS4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.