Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for YEATS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YEATS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YEATS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:183,428,041–183,429,327 | 269.0 kb | Distal (>10kb) Multiome | 572 | |
| chr3:183,433,737–183,435,984 | 263.2 kb | Distal (>10kb) Multiome | 282 | |
| chr3:183,447,193–183,447,991 | 250.3 kb | Distal (>10kb) Multiome | 926 | |
| chr3:183,544,658–183,545,145 | 152.9 kb | Distal (>10kb) Multiome | 164 | |
| chr3:183,635,238–183,637,215 | 62.3 kb | Distal (>10kb) Multiome | 923 | |
| chr3:183,697,518–183,698,578 | 84 bp | At TSS Multiome | 787 | |
| chr3:183,824,588–183,826,123 | 127.8 kb | Distal (>10kb) Multiome | 467 | |
| chr3:183,883,494–183,884,017 | 185.8 kb | Distal (>10kb) Multiome | 83 | |
| chr3:183,884,110–183,885,311 | 187.1 kb | Distal (>10kb) Multiome | 972 | |
| chr3:183,912,940–183,913,709 | 215.5 kb | Distal (>10kb) Multiome | 225 |
Genomic view of the YEATS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.