This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for YAF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YAF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YAF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:41,967,605–41,968,483 | 270.0 kb | Distal (>10kb) Multiome | 252 | |
| chr12:42,144,190–42,146,161 | 93.4 kb | Distal (>10kb) Multiome | 923 | |
| chr12:42,237,254–42,239,022 | 605 bp | At TSS Multiome | 833 | |
| chr12:42,240,296–42,240,713 | 2.1 kb | Proximal (<10kb) | 38 | |
| chr12:42,325,595–42,326,457 | 87.8 kb | Distal (>10kb) Multiome | 748 | |
| chr12:42,482,483–42,484,824 | 245.9 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the YAF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.