The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for XYLT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XYLT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XYLT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:50,055,522–50,057,280 | 290.2 kb | Distal (>10kb) Multiome | 654 | |
| chr17:50,094,331–50,095,951 | 250.9 kb | Distal (>10kb) Multiome | 899 | |
| chr17:50,117,038–50,117,876 | 228.8 kb | Distal (>10kb) Multiome | 488 | |
| chr17:50,150,777–50,152,506 | 195.1 kb | Distal (>10kb) Multiome | 900 | |
| chr17:50,161,052–50,162,135 | 184.5 kb | Distal (>10kb) Multiome | 691 | |
| chr17:50,177,880–50,178,665 | 167.8 kb | Distal (>10kb) Multiome | 675 | |
| chr17:50,199,586–50,201,292 | 145.6 kb | Distal (>10kb) Multiome | 798 | |
| chr17:50,273,066–50,273,646 | 72.9 kb | Distal (>10kb) Multiome | 411 | |
| chr17:50,274,084–50,274,945 | 71.6 kb | Distal (>10kb) Multiome | 242 | |
| chr17:50,310,314–50,311,981 | 34.5 kb | Distal (>10kb) Multiome | 314 | |
| chr17:50,312,127–50,312,775 | 33.4 kb | Distal (>10kb) Multiome | 37 | |
| chr17:50,345,523–50,346,998 | 8 bp | At TSS Multiome | 809 | |
| chr17:50,363,392–50,364,195 | 17.7 kb | Distal (>10kb) Multiome | 164 | |
| chr17:50,372,860–50,373,487 | 27.0 kb | Distal (>10kb) Multiome | 999 | |
| chr17:50,397,227–50,397,885 | 51.4 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:50,425,595–50,426,626 | 80.1 kb | Distal (>10kb) Multiome | 619 | |
| chr17:50,478,411–50,479,262 | 132.7 kb | Distal (>10kb) Multiome | 956 | |
| chr17:50,508,047–50,508,856 | 162.3 kb | Distal (>10kb) Multiome | 332 | |
| chr17:50,541,672–50,542,697 | 196.0 kb | Distal (>10kb) Multiome | 772 | |
| chr17:50,546,778–50,547,615 | 201.0 kb | Distal (>10kb) Multiome | 786 | |
| chr17:50,558,590–50,561,781 | 214.4 kb | Distal (>10kb) Multiome | 587 | |
| chr17:50,586,525–50,587,142 | 240.7 kb | Distal (>10kb) Multiome | 43 | |
| chr17:50,634,652–50,635,325 | 288.9 kb | Distal (>10kb) Multiome | 471 |
Genomic view of the XYLT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.