Enables magnesium ion binding activity; manganese ion binding activity; and xylosyl alpha-1,3-xylosyltransferase activity. Involved in O-glycan processing. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for XXYLT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XXYLT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XXYLT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:195,106,453–195,106,932 | 164.5 kb | Distal (>10kb) Multiome | 491 | |
| chr3:195,117,791–195,118,489 | 153.0 kb | Distal (>10kb) Multiome | 327 | |
| chr3:195,150,284–195,150,801 | 120.5 kb | Distal (>10kb) Multiome | 462 | |
| chr3:195,259,295–195,260,886 | 10.9 kb | Distal (>10kb) Multiome | 943 | |
| chr3:195,270,082–195,272,177 | 138 bp | At TSS Multiome | 1024 | |
| chr3:195,297,445–195,298,276 | 26.8 kb | Distal (>10kb) Multiome | 66 | |
| chr3:195,442,104–195,443,858 | 172.0 kb | Distal (>10kb) Multiome | 857 | |
| chr3:195,542,767–195,544,250 | 272.2 kb | Distal (>10kb) Multiome HiCAR | 765 |
Genomic view of the XXYLT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.