The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for XRCC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XRCC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XRCC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:42,313,206–42,313,892 | 1266.9 kb | Distal (>10kb) Multiome HiCAR | 515 | |
| chr19:43,463,046–43,464,465 | 116.9 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,474,993–43,475,696 | 105.1 kb | Distal (>10kb) Multiome | 506 | |
| chr19:43,503,542–43,505,032 | 76.2 kb | Distal (>10kb) Multiome | 760 | |
| chr19:43,526,489–43,527,639 | 53.2 kb | Distal (>10kb) Multiome | 712 | |
| chr19:43,532,595–43,534,553 | 46.4 kb | Distal (>10kb) Multiome | 698 | |
| chr19:43,575,342–43,576,244 | 4.8 kb | Proximal (<10kb) Multiome | 562 | |
| chr19:43,580,271–43,581,020 | 142 bp | At TSS Multiome | 151 | |
| chr19:43,594,710–43,596,874 | 15.8 kb | Distal (>10kb) Multiome | 998 | |
| chr19:43,618,905–43,620,391 | 39.3 kb | Distal (>10kb) Multiome | 1071 | |
| chr19:43,639,490–43,640,467 | 59.4 kb | Distal (>10kb) Multiome | 545 | |
| chr19:43,667,574–43,669,430 | 88.2 kb | Distal (>10kb) Multiome | 787 | |
| chr19:43,671,889–43,672,687 | 91.8 kb | Distal (>10kb) Multiome | 162 | |
| chr19:43,673,253–43,674,111 | 93.4 kb | Distal (>10kb) Multiome | 55 | |
| chr19:43,754,239–43,755,900 | 174.3 kb | Distal (>10kb) Multiome | 899 | |
| chr19:43,773,845–43,774,908 | 194.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:43,798,557–43,799,046 | 218.4 kb | Distal (>10kb) Multiome | 403 | |
| chr19:43,827,133–43,827,702 | 246.9 kb | Distal (>10kb) Multiome | 593 |
Genomic view of the XRCC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.